ALOX5AP Antibody(Center)
Cat.#: T2854
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: P20292
Mol Weight: 18kDa
Size: 100ug

Description
ALOX5AP is a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation.

Recommended Applications
WB, IHC, ELISA

Applications and Recommended Dilution Factors
WB: 1:50~100
IHC: 1:50~100
ELISA: 1:1,000

Species Reactivity
Human

Products Data 

 

Western blot analysis of anti-ALOX5AP Antibody (Center) in K562 cell line lysates (35ug/lane). ALOX5AP(arrow) was detected using the purified Pab.
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with ALOX5AP antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Specificity
This ALOX5AP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94~124 amino acids from the Center region of human ALOX5AP.

Storage Condition and Buffer
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Alternative Names
ALOX5AP antibody, FLAP antibody, Arachidonate 5-lipoxygenase-activating protein antibody, FLAP antibody, MK-886-binding protein antibody

Description References
Zintzaras,E., Am. J. Epidemiol. 169 (5), 523-532 (2009)
Crosslin,D.R., Hum. Genet. 125 (2), 217-229 (2009)
Steinhilber,D., Pharm Acta Helv 69 (1), 3-14 (1994)