耗材描述

• 分子式 C₂₁H₁₉N₅O₂S
• 分子量405.47
• Beilstein号
• EC号
• MDL号
• PubChem编号

属性

溶解性	25°C: DMSO 2mg/mL
存贮条件	储存温度-20°C

描述

产品介绍	BAM7是一种直接的，选择性的促凋亡Bax激动剂，EC50为3.3 μM
备注	BAM 7 is a direct and selective activator of proapoptotic Bax with EC50 of 3.3 μM.
生化机理	BAM7 is a selective activator of BAX, a proapoptotic member of the BCL-2 protein family. BAM7 binds directly to the BAX trigger site, a distinct BH3 binding site that regulates BAX activation, inducing BAX oligomerization, which enables the release of apoptogenic factors that result in cell death. BAM7 is selective for this previously unknown BH3-binding groove on the N-terminal face of BAX
别名	3-甲基-1-(4-苯基-2-噻唑基)-1H-吡唑-4,5-二酮 4-[2-(2-乙氧基苯基)腙];BAM 7;BAM-7；4-(2-(2-Ethoxyphenyl)hydrazono)-3-methyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-5(4H)-one；BAX activator molecule 7

信号词	Warning
危害声明	H302
WGK德国	3

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