10058-F4
面议
- 阿拉丁
- 生产商
- 国产
- 上海
- 现货
- 全国
- 1
- 1
分子式 C12H11NOS2 分子量249.35 Beilstein号 EC号 MDL号 MFCD00758517 PubChem编号 属性 溶解性 Soluble in DMSO: >10 mg/mL and Water: <
| 货号 | CAS号 | 操作 |
|---|---|---|
| F129209-25mg | 403811-55-2 | 询底价 |
耗材描述
- 分子式 C12H11NOS2
- 分子量249.35
- Beilstein号
- EC号
- MDL号 MFCD00758517
- PubChem编号
属性
| 溶解性 | Soluble in DMSO: >10 mg/mL and Water: <2 mg/mL |
| 存贮条件 | 储存温度2-8℃ |
描述
| 应用 | A c-Myc inhibitor and apoptosis inducer. |
| 产品介绍 | 10058-F4是一种c-Myc抑制剂，特异性抑制c-Myc-Max相互作用，且抑制c-Myc靶基因表达的转录激活。 |
| 备注 | 10058-F4 is a c-Myc inhibitor that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression. |
| 生化机理 | 10058-F4 is a c-Myc inhibitor that prevents c-Myc/Max dimerization. c-Myc is a proto-oncogene that plays an important role in cell proliferation, differentiation, and apoptosis. 10058-F4 has been shown to arrest cell growth at G0/G1 phase. Experiments show that 10058-F4 is a c-Myc inhibitor that prevents c-Myc/Max dimerization. c-Myc is a proto-oncogene that plays an important role in cell proliferation, differentiation, and apoptosis. 10058-F4 has been shown to arrest cell growth at G0/G1 phase. Experiments show that extended exposure to 10058-F4 causes apoptosis via upregulation of Bax, expression of cytoplasmic Cytochrome C, down-regulation of Bcl-2, and cleavage of caspase-3,-7, and -9. This compound has been found to also upregulate cyclin-dependent kinase inhibitors, p21 and p27. |
| 别名 | 5-[(4-乙基苯基)亚甲基]-2-硫代-4-噻唑烷酮;5-(4-乙基苯亚甲基)绕丹宁;5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone |
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