Temozolomide
面议
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分子式 C6H6N6O2 分子量194.15 MDL号 MFCD00866492 属性 敏感性 对热敏感 溶解性 Soluble in water (5 mg/ml at 25 °C), DMSO (39 mg/ml at 25 °C),
| 货号 | CAS号 | 操作 |
|---|---|---|
| T127425-500mg | 85622-93-1 | 询底价 |
| T127425-250mg | 85622-93-1 | 询底价 |
| T127425-100g | 85622-93-1 | 询底价 |
| T127425-5g | 85622-93-1 | 询底价 |
| T127425-1g | 85622-93-1 | 询底价 |
耗材描述
- 分子式 C6H6N6O2
- 分子量194.15
- MDL号 MFCD00866492
属性
| 敏感性 | 对热敏感 |
| 溶解性 | Soluble in water (5 mg/ml at 25 °C), DMSO (39 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C). |
| 存贮条件 | 储存温度 2-8°C |
描述
| 应用 | An apoptosis inducer which causes arrest at the G2/M cell cycle checkpoint. |
| 产品介绍 | Temozolomide是一种DNA损伤诱导剂。 |
| 生化机理 | Temozolomide is an antitumor, antiangiogenic compound that has been shown to work by alkylating DNA, typically through addition of a methyl group to guanine in genomic DNA. The efficacy of this compound is dependent on its ability to methylate the DNA, thus triggering apoptosis; however, some cells are able to repair this damage via the enzymes O-6-methylguanine-DNA methyltransferase (MGMT). As a enzyme. Research has also been conducted to determine whether MGMT inhibitors such as O-6-benzylguanine might help to increase the efficacy of temozolomide. Furthermore, temozolomide has been implicated in causing arrest at the G2/M cell cycle checkpoint, which might also play a role in its cytotoxicity. |
| 别名 | 替莫唑胺;3,4-二氢-3-甲基-4-氧代咪唑并[5,1-d]-1,2,3,5-四嗪-8-甲酰胺;8-氨基甲酰基-3-甲基咪唑[5,1-d]并-1,2,3,5-四氮嗪-4-(3H)-酮;4-甲基-5-氧代-2,3,4,6,8-五氮杂双环[4.3.0]壬-2,7,9-三烯-9-甲酰胺; 3-甲基-4-氧代-8-咪唑并[5,1-d][1,2,3,5]四嗪甲酰胺;NSC 362856; CCRG 81045; TZM;3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide |
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