Nocodazole
面议
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分子式 C14H11N3O3S 分子量301.32 Beilstein号 1085978 EC号 250-626-5 MDL号 MFCD00005588 PubChem编号 24278535 属性 熔点 260 °C 敏感性 对热敏感 溶解
| 货号 | CAS号 | 操作 |
|---|---|---|
| N129755-10mg | 31430-18-9 | 询底价 |
| N129755-250mg | 31430-18-9 | 询底价 |
| N129755-50mg | 31430-18-9 | 询底价 |
耗材描述
- 分子式 C14H11N3O3S
- 分子量301.32
- Beilstein号 1085978
- EC号 250-626-5
- MDL号 MFCD00005588
- PubChem编号 24278535
属性
| 熔点 | 260 °C |
| 敏感性 | 对热敏感 |
| 溶解性 | Soluble in DMSO (10 mg/ml);Soluble in Ethanol (1 mg/ml) |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A potent Tubulin production inhibitor and anti-neoplastic agent |
| 产品介绍 | Nocodazole is a reversible anti-neoplastic agent which exerts its effect in cells by interfering with the polymerization of microtubules (tubulin). Several drugs including vincristine and colcemid are similar to nocodazole in that they interfere with microtubule polymerization. Nocodazole is frequently employed in cell biology laboratories to synchronize the cell division cycle; cells treated with nocodazole arrest with a G2- or M-phase DNA content when analyzed by flow cytometry. Nocodazole has also been used to induce the formation of Golgi ministacks in eukaryotic cells due to lack of proper Tubulin function. |
| 备注 | Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM, respectively. |
| 生化机理 | Nocodazole是一种微管聚合的快速可逆抑制剂，也抑制Abl， Abl(E255K)和Abl(T315I)，IC50分别为0.21 μM， 0.53 μM和0.64 μM。 |
| 别名 | 诺考达唑;[5-(2-噻吩羰基)-1H-苯并咪唑-2-基]氨基甲酸甲酯 ;Oncodazole;R 17934;Methyl N-(5-thenoyl-2-benzimidazolyl)carbamate;Methyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate;[5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamic acid methyl ester |
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