耗材描述

• 分子式 C₂₅H₂₈N₆O
• 分子量428.53
• Beilstein号
• EC号
• MDL号 MFCD00864464
• PubChem编号

属性

溶解性	Soluble in DMSO (>25 mg/ml), ethanol (~0.5 mg/ml), methanol, DMF (~20 mg/ml), and water (<1 mg/ml at 25 °C).
存贮条件	储存温度2-8℃

描述

应用	An angiotensin II type 1 (AII1)-receptor antagonist.
产品介绍	Irbesartan是一种高效的特定血管紧张素II 1型(AT1)受体拮抗剂，IC50为1.3 nM。
备注	Irbesartan (SR-47436, BMS-186295) is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.
生化机理	Irbesartan is a highly potent and selective antagonist of the AT1 (angiotensin II type 1) receptor with an IC50 = 1.3 nM. This compound has no affinity for AT2 receptors. Pretreatment with irbesartan decreases angiotensin II-induced apoptosis in rat vascular smooth muscle cells by blocking angiotensin II internalization in a concentration-dependent manner.
别名	伊贝沙坦; 2-丁基-3-[4-[2-(1H-四唑-5-基)苯基]苄基]-1,3-二氮杂螺-[4.4]壬-1-烯-4-酮;BMS-186295;SR-47436;Avapro;3-Butyl-2-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-2,4-diazaspiro[4.4]non-3-en-1-one;2-Butyl-3-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one

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