Phenoxybenzamine HCl
面议
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分子式 C18H22ClNO·HCl 分子量340.3 EC号 200-569-7 MDL号 MFCD00055152 PubChem编号 24277760 属性 溶解性 DMSO 68 mg/mL Water 17 mg/mL Ethan
| 货号 | CAS号 | 操作 |
|---|---|---|
| P129843-5g | 63-92-3 | 询底价 |
| P129843-1g | 63-92-3 | 询底价 |
| P129843-25g | 63-92-3 | 询底价 |
耗材描述
- 分子式 C18H22ClNO·HCl
- 分子量340.3
- EC号 200-569-7
- MDL号 MFCD00055152
- PubChem编号 24277760
属性
| 溶解性 |
|
| 存贮条件 | 储存温度 2-8°C |
描述
| 应用 | A non-specific irreversible adrenergic (AR) antagonist. |
| 产品介绍 | Phenoxybenzamine HCl是一种非选择性，不可逆α受体拮抗剂，IC50为550 nM。 |
| 备注 | Phenoxybenzamine HCl is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM. |
| 生化机理 | Phenoxybenzamine is a cell-permeable, non-specific, irreversible AR (α-adrenergic) antagonist that also acts as an CaM inhibitor. Phenoxybenzamine inhibits calmodulin-stimulated phosphodiesterase activity. This product has been shown to inhibit cGMP accumulation in cerebellar cells evoked by an exogenous nitric oxide donor. Phenoxybenzamine has been used to generate a novel glucocorticoid receptor that complexes with HSP90, but has no hormone binding ability. This compound has also been employed to block high levels of catecholamines. |
| 别名 | 竹林胺;酚苄胺;苯氧苄胺;盐酸苯氧苄胺;N-(1-甲基-2-苯氧乙基)-N-(2-氯乙基)苯甲胺盐酸盐;Dibenzyline Hydrochloride;N-Phenoxyisopropyl-N-benzyl-2-chloroethylamine Hydrochloride;N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine Hydrochloride |
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