PF-543-分析测试百科网

PF-543

面议

品牌：阿拉丁
厂商性质：生产商
产地类别：国产
产地：上海
货期：现货
服务地域：全国
规格：4
近期咨询：0

分子式 C27H31NO4S 分子量465.6 属性溶解性 DMSO mg/mL Water mg/mL Ethanol mg/mL 存贮条件储存温度-20°C //decorateTable('product-attribute-sp

上海阿拉丁生化科技股份有限公司

上海阿拉丁生化科技股份有限公司

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货号	CAS号	操作
P125702-10mg	1415562-82-1	询底价
P125702-1mg	1415562-82-1	询底价
P125702-50mg	1415562-82-1	询底价
P125702-5mg	1415562-82-1	询底价

耗材描述

分子式 C₂₇H₃₁NO₄S
分子量465.6

属性

溶解性	DMSO mg/mL Water mg/mL Ethanol mg/mL
存贮条件	储存温度-20°C

描述

备注	PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and K_i of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform.
生化机理	PF-543 is a novel cell-permeant inhibitor of SphK1. PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. PF-543 is the most potent inhibitor of SphK1 described to date and it will be useful for dissecting specific roles of SphK1-driven S1P signalling.
别名	2-Pyrrolidinemethanol, 1-[[4-[[3-methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-, (2R)-;2-Pyrrolidinemethanol, 1-[[4-[[3-methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-, (2R)-

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