ZM 39923 HCl-分析测试百科网

ZM 39923 HCl

面议

品牌：阿拉丁
厂商性质：生产商
产地类别：国产
产地：上海
货期：现货
服务地域：全国
规格：3
近期咨询：1

分子式 C23H25NO.HCl 分子量367.91 属性溶解性 DMSO 30 mg/mL Water <1 mg/mL Ethanol 8 mg/mL 存贮条件储存温度-20°C //decorateTable('produc

上海阿拉丁生化科技股份有限公司

上海阿拉丁生化科技股份有限公司

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货号	CAS号	操作
Z129618-50mg	1021868-92-7	询底价
Z129618-250mg	1021868-92-7	询底价
Z129618-10mg	1021868-92-7	询底价

耗材描述

分子式 C₂₃H₂₅NO.HCl
分子量367.91

属性

溶解性	DMSO 30 mg/mL Water <1 mg/mL Ethanol 8 mg/mL
存贮条件	储存温度-20°C

描述

产品介绍	ZM39923盐酸盐是一种JAK1/3抑制剂, pIC50 of 4.4/7.1, 对JAK2几乎没有抑制活性。
生化机理	ZM39923 is a JAK3 inhibitor. ZM39923 is also a potent inhibitor of TGM2 with IC50 of 10 nM. ZM39923 is reversible inhibitors when TGM2 is incubated with inhibitors in the absence of Ca2+. ZM39923 shows significant inhibition of crosslinking activity with IC50 of 25 nM in the absence of DTT and IC50 of 10 μM in the presence of DTT. ZM39923 prevents early death in a Drosophila Melanogaster model of a polyQ repeat disorder called Machado-Joseph Disease. ZM39923 inhibits the generation of AICD-FLAG and both Aβ40 and Aβ42 by purified γ-secretase in a concentration-dependent fashion with an approximate IC50 of 20 μM. ZM39923 decreases photoaffinity-labeled PS1-CTF in the presense of γ-secretase.
别名	3-(异丙基(苄基)氨基)-1-(2-萘基)-1-丙酮盐酸盐;ZM-39923 hydrochloride; ZM39923 hydrochloride;3-((1-methylethyl)(phenylmethyl)amino)-1-(2-naphthalenyl)-1-propanone hydrochloride;

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