耗材描述

• 分子式 C₂₆H₂₆F₂N₂·2HCl
• 分子量477.42
• Beilstein号 4284243
• EC号 250-216-6
• MDL号 MFCD00058198
• PubChem编号 24277835

属性

溶解性	Soluble in DMSO (25 mg/mL), ethanol (5 mg/mL warm), methanol, 0.1N HCI, and chloroform/methanol (9:1) (50 mg/mL). Insoluble in water, and dilute aqueous base..
存贮条件	储存温度 2-8°C

描述

应用	A calcium channel protein inhibitor.
产品介绍	Flunarizine 2HCl是一种二氢盐酸盐，抑制钙离子通道，Ki为68 nM。
备注	Flunarizine dihydrochloride is a dihydrochloride salt form which is a calcium channel blocker with a Ki of 68 nM.
生化机理	Flunarizine ? 2HCl, a calcium channel protein inhibitor and antagonist, has been shown to inhibit contraction of isolated murine caudal artery preparations. Mechanistic studies suggest that this compound inhibits prostaglandin-induced and Serotonin ? HCl induced components of the contraction via reduction in the amounts of TXB2 (Thromboxane B2) and ALK-1, and an increase in production of HETE. Experiments on rabbit sino-atrial nodes and isolated guinea-pig papillary muscles have reported that Flunarizine ? 2HCl depressed the slow action potentials of K+-depolarized papillary muscle. Additionally, studies indicate that Flunarizine ? 2HCl selectively suppresses Ca2+ influx through the cell membrane of sino-atrial nodes.
别名	盐酸氟桂利嗪; (E)-1-[双(4-氟苯基)甲基]-4-(3-苯基-2-丙烯基)-哌嗪二盐酸盐;1-[双(4-氟苯基)甲基]-4-(3-苯基-2-丙烯基)哌嗪 二盐酸盐;Sibelium;Flunarizine dihydrochloride;1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride

标识符号	GHS07
信号词	Warning
危害声明	H302
个人防护设备	dust mask type N95 (US), Eyeshields, Gloves
RTECS	TK9187000
WGK德国	3

猜你喜欢

• 

  根皮素

• 

  Ivacaftor (VX-770)

• 

  Azelnidipine

• 

  Vonoprazan Fumarate (TAK-438)

• 

  吡那地尔

• 

  Cleviprex

• 

  NP118809

• 

  A-803467

• 

  Vigabatrin

• 

  Pregabalin

感兴趣产品

• Flunarizine 2HCl价格
• Flunarizine 2HCl厂商
• Flunarizine 2HCl规格