WY-14643 (Pirinixic Acid)-分析测试百科网

WY-14643 (Pirinixic Acid)

面议

品牌：阿拉丁
厂商性质：生产商
产地类别：国产
产地：上海
货期：现货
服务地域：全国
规格：3
近期咨询：1

分子量323.80 属性溶解性 Soluble in DMSO (65 mg/ml at 25 °C), ethanol (52 mg/ml at 25 °C), DMF (~16.5 mg/ml), PBS (pH 7.2, ~0.04

上海阿拉丁生化科技股份有限公司

上海阿拉丁生化科技股份有限公司

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货号	CAS号	操作
W129766-5g	50892-23-4	询底价
W129766-1g	50892-23-4	询底价
W129766-250mg	50892-23-4	询底价

耗材描述

分子量323.80

属性

溶解性	Soluble in DMSO (65 mg/ml at 25 °C), ethanol (52 mg/ml at 25 °C), DMF (~16.5 mg/ml), PBS (pH 7.2, ~0.04 mg/ml), and water (<1 mg/ml at 25 °C).

描述

应用	A highly potent PPARα agonist
产品介绍	WY-14643 (Pirinixic Acid)是一种有效的过氧化物酶体增殖子和PPARα激活剂，EC50为1.5 μM。
备注	WY 14643 (Pirinixic Acid) is a potent peroxisome proliferator and activator of PPARα with EC50 of 1.5 μM.
生化机理	WY 14643 is a highly potent PPARα agonist. Peroxisome proliferator-activated receptors (PPARs) α, β, and γ are hormone receptors that induce the gene acyl-Coa and modulate the peroxisomal beta oxidation of fatty acids. WY 14643 has been shown to inhibit TNF-α-induced VCAM-1, and reduce TNF-α and IL-1β. Studies indicate that WY 14643 inhibits proliferation of trophoblast cells at lower concentrations than clofibric acid, and decreases the levels of S-100 β chain (S100B) protein.
别名	[4-氯-6-(2,3-茬胺基)-2-嘧啶硫代]乙酸;匹立尼酸;4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid;Pirinixic acid;WY 14643

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