Clomipramine HCl
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分子式 C19H23ClN2·HCl 分子量351.31 Beilstein号 EC号 241-344-3 MDL号 MFCD00069234 PubChem编号 24278087 属性 敏感性 对热和光敏感 溶解性 Soluble in
| 货号 | CAS号 | 操作 |
|---|---|---|
| C129687-25g | 17321-77-6 | 询底价 |
| C129687-5g | 17321-77-6 | 询底价 |
| C129687-1g | 17321-77-6 | 询底价 |
耗材描述
- 分子式 C19H23ClN2·HCl
- 分子量351.31
- Beilstein号
- EC号 241-344-3
- MDL号 MFCD00069234
- PubChem编号 24278087
属性
| 敏感性 | 对热和光敏感 |
| 溶解性 | Soluble in water (125 mg/ml), ethanol (70 mg/ml at 25 °C), chloroform (1:3), DMSO (70 mg/ml at 25 °C), and dilute aqueous acid. |
描述
| 应用 | A selective ST, SLC6A2, and DAT inhibitor |
| 产品介绍 | Clomipramine HCl 是Clomipramine的盐酸盐，抑制5-羟色胺转运蛋白（SERT），去甲肾上腺素转运体（NET）和多巴胺转运蛋白（DAT），Ki分别为0.14， 54和3 nM。 |
| 备注 | Clomipramine hydrochloride (Anafranil) is a hydrochloride salt of clomipramine which is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively. |
| 生化机理 |
Clomipramine hydrochloride (Anafranil) is a hydrochloride salt of clomipramine which is an ST (serotonin transporter/SERT), SLC6A2 (norepinephrine transporter/NET), and DAT (dopamine transporter) blocker with Ki of 0.14, 54 and 3 nM, respectively. Clomipramine hydrochloride is a tricyclic antidepressant, a norepinephrine-reuptake inhibitor, and an antiobsessional drug. Clomipramine hydrochloride is an inhibitor of D2 receptor (Ki = 162 nM), D3 receptor (Ki = 30 nM), AR (α1-adrenergic receptor, Ki = 3.2 nM), α2-adrenergic receptor (Ki = 525 nM), H1 receptor (Ki = 31 nM), mACh receptors (Ki = 37 nM), 5-HT2A receptor (Ki = 36 nM), 5-HT2C receptor (Ki = 65 nM), 5-HT3 receptor (Ki = 85 nM), 5-HT6 receptor (Ki = 54 nM), 5-HT7 receptor (Ki = 127 nM), D1 receptor (Ki = 219 nM). |
| 别名 | 盐酸氯米帕明;氯丙咪嗪盐酸盐;Anafranil hydrochloride;Clomipramine hydrochloride |
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