耗材描述

• 分子式 C₁₂H₉ClN₂O
• 分子量232.67
• Beilstein号
• EC号
• MDL号
• PubChem编号

属性

溶解性	DMSO 47 mg/mL Water <1 mg/mL Ethanol 47 mg/mL
存贮条件	储存温度-20°C

描述

应用	A postitive allosteric modulator of mGluR-4
产品介绍	VU 0364770 is a positive allosteric modulator(PAM) of mGlu4 with EC50 of 1.1 μM, exhibits insignificant activity at 68 other receptors, including other mGlu subtypes.
备注	VU 0364770 is a positive allosteric modulator(PAM) of mGlu4 with EC50 of 1.1 μM, exhibits insignificant activity at 68 other receptors, including other mGlu subtypes.
生化机理	VU 0364770 is a positive allosteric modulator of mGluR-4 (EC50 = 290 nM in mGluR-4-expressing HEK 293 cells). VU 0364770 acts in many other ways such as the reversal of haloperidol-induced catalepsy in rats; and in rodent models of Parkinson's disease, preventing attentional deficit and forelimb asymmetry.
别名	N-(3-氯苯基)-2-吡啶甲酰胺;N-(3-Chlorophenyl)-2-pyridinecarboxamide

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