耗材描述

• 分子式 C₁₁H₁₃IN₄O₄
• 分子量392.15
• Beilstein号
• EC号
• MDL号 MFCD00055131
• PubChem编号

属性

溶解性	Soluble in DMSO (25 mg/ml), 100% ethanol (8 mg/ml warm), 0.1 M HCl (0.7 mg/ml), 0.1 M NaOH (0.8 mg/ml), methanol, and 1:1 mixture of DMSO:methanol (17 mg/ml).
存贮条件	储存温度2-8℃

描述

应用	A potent and competitive inhibitor of ERK2, PKA, and ADK.
产品介绍	5-Iodotubercidin(NSC 113939; 5-ITu) is a potent adenosine kinase inhibitor (IC50 = 26 nM).
生化机理	5-Iodotubercidin (Itu) has been shown to inhibit mitogen-activated protein kinase (ERK2) (Ki = 525 nM), adenosine kinase (ADK) (Ki = 30 nM), casein kinases 1 & 2 (CSNK1A1 & CSNK2A1), protein kinase A (PKA) and insulin receptor kinase (IC50 ranging from 0.4-28 μM). Itu has been suggested to be a general protein kinase inhibitor
别名	5-碘代杀结核菌素;NSC 113939; 5-ITu; 4-Amino-5-iodo-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine;5-Iodo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4- amine;7-Iodo-7-deazaadenosine

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