I-BET151-分析测试百科网

I-BET151

面议

分子式 C23H21N5O3 分子量415.44 Beilstein号 EC号 MDL号 PubChem编号属性溶解性 DMSO 100 mM Ethanol 100 mM 存贮条件储存温度2-8℃ //decorateTable('

400-6699-117 转1000

耗材描述

溶解性	DMSO 100 mM Ethanol 100 mM
存贮条件	储存温度2-8℃

生化机理	I-BET151 is a BET bromodomain inhibitor; I-BET151 blocks recruitment of BET to chromatin. I-BET151 induces apoptosis and G0/G1 cell cycle arrest in MLL-fusion leukemic cell lines in vitro (IC50 values are 15, 26, 120 and 192 nM for NOMO1, MV4;11, MOLM13 and RS4;11 cell lines respectively). I-BET151 reduces BCL2 expression in NOMO1 cells. I-BET151 improves survival in two rodents models of MLL-fusion leukemia in vivo.
别名	;7-(3，5-Dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[(1R)-1-(2-pyridinyl)ethyl]-1，3-dihydro-2H-imidazo[4，5-c]quinolin-2-one，I-BET151