CVT-313 is a cell-permeable purine analog that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk2 (IC50 = 0.5 ?M for Cdk2/A and Cdk2/E; 4.2 ?M for Cdk1/B; 215 ?M for Cdk4/D1). CVT-313 inhibits other kinases only at much higher concentrations (IC50 > 1.25 mM for MAPK, PKA, and PKC). CVT-313 shown to induce tumor cells growth arrest (IC50 ~1.25-20 ?M) in vitro and prevent neointima formation in vivo.