耗材描述

• 分子式 C₂₁H₂₇N₇O
• 分子量393.49
• MDL号 MFCD07784513
• PubChem编号 24724590

属性

溶解性	DMSO: soluble7 mg/mL;H2O: insoluble
存贮条件	储存温度 2-8°C

描述

产品介绍	Reversine是合成的嘌呤类似物，能抑制Aurora A/B/C，IC50为150到500 nM。
生化机理	Reversine is a cell-permeable, 2,6-disubstituted purine analog that acts as a dedifferentiation-inducing agent. Reversine is shown to induce mouse C2C12 myoblast cells to become multipotent mesenchymal progenitor cells in the concentration range of 1-10 μM. Reversine is also the first organic molecule that has been demonstrated to reverse the cellular differentiation process. The compound acts as a selective A3 adenosine receptor antagonist (Ki= 660 nM, >10 μM, and >10 μM for hA3, hA1, and hA2A, respectively. Reversine functions as a dual inhibitor of MEK1 and nonmuscle myosin II heavy chain (IC50 = 8 and 10 nM, respectively). The compound also acts as an ATP-competitive, reversible and selective inhibitor of ARK-1, ARK-2, and ARK-3 (IC50 = 400, 500 and 400 nM, respectively) in a 26-kinase panel.
别名	;N6-Cyclohexyl-N2-[4-(4-morpholinyl)phenyl]-1H-purine-2,6-diamine;2-(4-Morpholinoanilino)-6-cyclohexylaminopurine

标识符号	GHS07
信号词	Warning
危害声明	H302
个人防护设备	dust mask type N95 (US), Eyeshields, Gloves
WGK德国	3

猜你喜欢

• 

  Novex®NuPAGE®预混合缓冲液和试剂

• 

  KN-92

• 

  Chlorpropamide

• 

  Tozadenant

• 

  F-7876维生素M[叶酸]

• 

  Fmoc-D-2-硝基苯丙氨酸

• 

  Boc-D-4-碘苯丙氨酸

• 

  Sparfloxacin

• 

  Chlorzoxazone

• 

  Zaurategrast

感兴趣产品

• Reversine价格
• Reversine厂商
• Reversine规格