| 应用 |
A modulator to human androgen receptor.
Ostarine at the concentration of 10 nM modulates the transcriptional activity of AR in CV-1 cells cotransfected with a human AR expression vector, a luciferase reporter vector, and a control β-galactosidase vector, with 94%-100% relative activity of the transcriptional activation observed for 1 nM DHT. |
| 产品介绍 |
MK-2866 (GTx-024)是一种selective androgen receptor modulator (SARM)（选择性雄激素受体调节剂） ， Ki为3.8 nM，作用于合成代谢器官具有组织选择性。Phase 3。 |
| 生化机理 |
Ostarine (MK-2866) is an androgen receptor modulator (SARM) with an ED50 of 0.44 mg/day. Ostarine (MK-2866) has anabolic activity. Lack of PSA increases in men and hair growth in women further corroborated selective anabolic effects of Ostarine (MK-2866). Ostarine (MK-2866) also resulted in a dose-dependent decrease in LDL and HDL cholesterol levels, with the average LDL/HDL ratio for all doses remaining in the low cardiovascular risk catergory. |
| 别名 |
MK-2866; MK 2866; GTX-024; Enobosarm;MK-2866 (GTx-024) ;(S)-N-(4-氰基-3-(三氟甲基)苯基)-3-(4-氰基苯氧基)-2-羟基-2-甲基丙酰胺;MK-2866; MK 2866; GTX-024; Enobosarm;(S)?-?3-?(4-?Cyanophenoxy)?-N-?[4-?cyano-?3-?(trifluoromethyl)?phenyl]?-?2-?hydroxy-?2-?methylpropionamide |
