| 应用 |
An inhibitor of Cox-1 and Cox-2, selective for Cox-2. |
| 产品介绍 |
Meloxicam 是一种非甾体类抗炎剂，具有镇痛和降低发烧作用。 |
| 备注 |
Meloxicam (Mobic) is a nonsteroidal anti-inflammatory agent with analgesic and fever reducer effects. |
| 生化机理 |
Meloxicam, a non-steroidal anti-inflammatory agent, has been reported to inhibit the inducible isoform of Cox-2. Meloxicam is an inhibitor selective for Cox-2 (IC50 of 4.7 μM) over Cox-1 (IC50 of 36.6 μM). Studies suggest that Meloxicam is Cox-2 preferential, therefore it will probably not display a lower gastrointestinal toxicity than non-selective anti-inflammatory agents. This compound has been shown to also inhibit prostanoid synthesis in inflammatory cells. Additionally, Meloxicam has demonstrated the ability to non-competitively inhibit erythrocyte PGD (6-phosphogluconate dehydrogenase) activity in vitro. |
| 别名 |
美洛昔康;4-羟基-2-甲基-N-(5-甲基-2-噻唑基)-2H-1,2-苯并噻嗪-3-甲酰胺-1,1-二氧化物;UH-AC 62XX;Mobic; Metacam; UH-AC 62XX; Coxicam;4-Hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide |
