耗材描述

• 分子式 C₁₇H₁₉N₃
• 分子量265.35
• Beilstein号
• EC号
• MDL号 MFCD00865427
• PubChem编号 24724531

属性

溶解性	Soluble to 50 mM in Ethanol and to 20 mM in DMSO
存贮条件	储存温度-20°C

描述

应用	A potent SR-2, SR-3, and Histamine H1 receptor antagonist.
产品介绍	Mirtazapine 是一种有效的四环抗抑郁剂。
备注	Mirtazapine is a potent tetracyclic antidepressant.
生化机理	Mirtazapine is a potent SR-2 (pKi 8.05) and SR-3 (pKi 8.1) antagonist in addition to being a moderately potent α2 adrenoceptor (pKi 6.9) and histamine H1 receptor antagonist (pKi 9.3). Mirtazapine has been observed to inhibit α2 adrenergic autoreceptors, enhancing noradrenaline release, as well as showing weak affinity for monoamine transporters. Mirtazapine has also been documented to increase hippocampal noradrenaline and serotonin.
别名	米尔塔扎平;1,2,3,4,10,14b-六氢-2-甲基吡嗪基-[2,1-a]吡啶并[2,3-c]氮杂卓;米氮平;Remeron; SolTab; Zispin; Org3770; 6-Azamianserin; Avanza;1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine

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