应用 |
An inhibitor of Cox-2 and tyrosine kinase. |
产品介绍 |
Leflunomide是免疫抑制剂,其活性代谢产物为A77 1726(RS-61980)。 |
备注 |
Leflunomide is an immunosuppressant agent. Its active metabolite is Teriflunomide. |
生化机理 |
Leflunomide is an immunosuppressive drug that inhibits T and B cell responses. Leflunomide is an inhibitor of Cox-2, of tyrosine phosphorylation (tyrosine kinase), of DHODH (dihydroorotate dehydrogenase), an enzyme for de novo pyrimidine synthesis, and of TNF-dependent NF-κB activation. The physiological activity of leflunomide is attributed mainly to its metabolite A77 1726. |
别名 |
5-甲基-N-[4-(三氟甲基)苯基]异恶唑-4-甲酰胺;来氟米特;HWA486; RS-34821; SU101;5-Methyl-N-[4-(trifluoromethyl)phenyl]isoxazole-4-carboxamide;5-Methylisoxazole-4-(4-trifluoromethyl)carboxanilide;HWA486; RS-34821; SU101 |