| 应用 |
A calcium channel andsodium channel protein inhibitor |
| 产品介绍 |
Amiloride ? HCl is a selective T-type calcium channel protein inhibitor that has been shown to inhibit the Polycystin-L channel (Polycystic kidney disease 2-like 1 protein: PKD2L1), a member of the transient receptor potential (TRP) superfamily of cation channels, including the NHE (sodium/hydgrogen exchanger). Amiloride is also an epithelial sodium channel protein inhibitor, which inhibits sodium reabsorption without affecting potassium concentrations. Amiloride serves as a non-selective acid-sensing ion channel (ASIC) blocker and a selective inhibitor of uPA (urokinase plasminogen activator). Research shows that amiloride reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 μM. Amiloride ? HCl is an inhibitor of Sodium/Potassium-ATPase Protein. |
| 备注 |
Amiloride hydrochloride(Midamor), a pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. |
| 生化机理 |
Selective T-type calcium channel blocker and blocker of epithelial sodium channel. Selective inhibitor of urokinase plasminogen activator (uPA). |
| 别名 |
盐酸阿米洛利;N-脒基-3,5-二氨基-6-氯吡嗪甲酰胺盐酸盐Midamor, Colectril, Amipramizide, Guanamprazine hydrochloride;1-(3,5-diamino-2-chloropyrazine-6-carbonyl)guanidine hydrochloride |
