MK-2206 2HCl-分析测试百科网

MK-2206 2HCl

面议

品牌：阿拉丁
厂商性质：生产商
产地类别：国产
产地：上海
货期：现货
服务地域：全国
规格：3
近期咨询：1

分子式 C25H21N5O·2HCl 分子量480.39 属性熔点 >225 °C 溶解性 Soluble in DMSO (≥92 mg/ml), water (≥92 mg/ml), ethanol (≥1.8 mg/ml),

上海阿拉丁生化科技股份有限公司

上海阿拉丁生化科技股份有限公司

加入购物车

加入购物车获取底价在线咨询

400-6699-117 转1000

货号	CAS号	操作
M129684-10mg	1032350-13-2	询底价
M129684-50mg	1032350-13-2	询底价
M129684-100mg	1032350-13-2	询底价

耗材描述

分子式 C₂₅H₂₁N₅O·2HCl
分子量480.39

属性

熔点	>225 °C
溶解性	Soluble in DMSO (≥92 mg/ml), water (≥92 mg/ml), ethanol (≥1.8 mg/ml), and methanol.
存贮条件	储存温度-20°C

描述

应用	A highly selective pan-Akt inhibitor activated by the pleckstrin homology domain
产品介绍	MK-2206 2HCl是一种高度选择性的Akt1/2/3抑制剂，IC50分别为8 nM/12 nM/65 nM；对250种其他蛋白激酶没有抑制活性。
备注	MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively; no inhibitory activities against 250 other protein kinases observed. Phase 2.
生化机理	MK-2206 2HCl is a highly selective inhibitor of Akt1, Akt2, and Akt3 with IC50 values of 8 nM, 12 nM and 65 nM, respectively. MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells
别名	MK2206; 8-[4-(1-氨基环丁基)苯基]-9-苯基-1,2,4-三唑并[3,4-f][1,6]萘啶-3(2H)-酮二盐酸盐;MK2206;MK-2206 dihydrochloride;8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride

猜你喜欢

感兴趣产品