| 应用 |
A selective inhibitor of mTOR kinase |
| 产品介绍 |
AZD2014是高效mTOR抑制剂，IC50为2.8 nM，对PI3K各亚型(α/β/γ/δ)的抑制性较弱。 |
| 备注 |
AZD2014 is a novel mTOR inhibitor with IC50 of 2.8 nM; highly selective against multiple PI3K isoforms (α/β/γ/δ). Phase 2. |
| 生化机理 |
AZD2014 is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor AZD2014 inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR, a serine/threonine kinase that is upregulated in a variety of tumors, plays an important role downstream in the PI3K/Akt/mTOR signaling pathway. |
| 别名 |
AZD 2014; AZD-2014 3-(2,4-双((3S)-3-甲基吗啉-4-基)吡啶并(5,6-e)嘧啶-7-基)-N-甲基苯甲酰胺;;AZD 2014; AZD-2014;3-(2,4-bis((3s)-3-methylmorpholin-4-yl)pyrido(5,6-e)pyrimidin-7-yl)-n-methylbenzamide;3-(2,4-bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-N-methylbenzamide |
