耗材描述

• 分子式 C₂₀H₂₀ClN₃
• 分子量337.86

属性

沸点	530.2 °C/760 mmHg
溶解性	DMSO ≥66mg/mL Water <1.2mg/mL Ethanol ≥4.6mg/mL
存贮条件	储存温度-20°C
密度	1.2000

描述

应用	A potent ATP-competitive inhibitor of Akt1, Akt2 and Akt3
产品介绍	AT7867是ATP竞争性Akt1/2/3和p70S6K/PKA抑制剂，IC50分别为32 nM/17 nM/47 nM和85 nM/20 nM，对AGC激酶家族以外的蛋白几乎无活性。
备注	AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the AGC kinase family.
生化机理	AT7867 is a potent and oral AKT and p70 S6 kinase inhibitor with an IC50 of 17 nM.
别名	4-(4-氯苯基)-4-[4-(1H-吡唑-4-基)苯基]哌啶;pyrazole-based inhibitor 9；4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine

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