耗材描述

• 分子式 C₂₅H₂₇FN₄O₃
• 分子量450.52

属性

溶解性	DMSO 90 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件	储存温度-20°C

描述

产品介绍	Cediranib (AZD2171)是一种高效的VEGFR(KDR)抑制剂，IC50为<1 nM，同时也抑制Flt1/4，IC50为5 nM/≤3 nM，此外对c-Kit和PDGFRβ也具有相似的抑制活性，对VEGFR的选择性比PDGFR-α， CSF-1R和Flt3分别高36倍， 110倍 和1000倍以上。Phase 3。
备注	Cediranib (AZD2171) is a highly potent VEGFR(KDR) inhibitor with IC50 of <1 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM, similar activity against c-Kit and PDGFRβ, 36-, 110-fold and >1000-fold selective more for VEGFR than PDGFR-
生化机理	Cediranib is VEGFR2 inhibitor. Cediranib inhibited VEGF-stimulated proliferation and KDR phosphorylation with IC50s of 0.4 and 0.5 nM, respectively.
别名	AZD2171;西地尼布;4-(4-氟-2-甲基吲哚-5-基氧基)-6-甲氧基-7-[3-(吡咯烷-1-基)丙氧基]喹唑啉;AZD-2171;AZD2171;Recentin;4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline

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