AMG-208-分析测试百科网

AMG-208

面议

品牌：阿拉丁
厂商性质：生产商
产地类别：国产
产地：上海
货期：现货
服务地域：全国
规格：2
近期咨询：1

分子式 C22H17N5O2 分子量383.41 属性溶解性 DMSO 0.25 mg/mL Water <1 mg/mL Ethanol <1 mg/mL 存贮条件储存温度-20°C //decorateTable('pr

上海阿拉丁生化科技股份有限公司

上海阿拉丁生化科技股份有限公司

加入购物车

加入购物车获取底价在线咨询

400-6699-117 转1000

货号	CAS号	操作
A127592-10mg	1002304-34-8	询底价
A127592-50mg	1002304-34-8	询底价

耗材描述

分子式 C₂₂H₁₇N₅O₂
分子量383.41

属性

溶解性	DMSO 0.25 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件	储存温度-20°C

描述

应用	A highly selective Met inhibitor (IC50 = 9.3 nM)
产品介绍	AMG-208是c-Met抑制剂，IC50为9.3 nM。
备注	AMG 208 is a highly selective c-Met inhibitor with IC50 of 9 nM. Phase 1.
生化机理	AMG-208 shows the potent inhibition of kinase c-Met activity with IC50 of 9 nM in a cell-free assay. Besides, AMG-208 treatment also leads to the inhibition of HGF-mediated c-Met phosphorylation in PC3 cells with IC50 of 46 nM . Pre-incubation of AMG-208 with human liver microsomes for 30 minutes shows a potent time-dependent inhibition for CYP3A4 metabolic activity with IC50 of 4.1 μM, which is an eightfold decrease relative to the IC50 (32 μM) without preincubation . AMG-208 is identified to be a c-MET and RON dual selective inhibitor
别名	AMG208; AMG 208; 7-甲氧基-4-((6-苯基-1,2,4-三唑并(4,3-b)哒嗪-3-基)甲氧基)喹啉;;AMG208; AMG 208;7-methoxy-4-((6-phenyl-1,2,4-triazolo(4,3-b)pyridazin-3-yl)methoxy)quinoline

猜你喜欢

感兴趣产品