SANT-1
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分子式 C23H27N5 分子量373.49 属性 熔点 109-111° C 折光率 1.62 溶解性 DMSO 21 mg/mL Water <1 mg/mL Ethanol 20 mg/mL 存贮条件 储存温度-20°C //d
| 货号 | CAS号 | 操作 |
|---|---|---|
| S129830-25mg | 304909-07-7 | 询底价 |
| S129830-5mg | 304909-07-7 | 询底价 |
| S129830-100mg | 304909-07-7 | 询底价 |
耗材描述
- 分子式 C23H27N5
- 分子量373.49
属性
| 熔点 | 109-111° C |
| 折光率 | 1.62 |
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | Treatment of Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma cells2 and chronic lymphocytic leukemia cells3 with SANT-1 induced cell death. |
| 产品介绍 | SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM. |
| 备注 | SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM. |
| 生化机理 | SANT-1 inhibited Sonic hedgehog signaling and induced apoptosis via Ras/NF-κB pathway in glioblastoma cells. SANT-1 is a potent sonic hedgehog pathway (Shh) antagonist that directly inhibits by binding to the smoothened (Smo) receptor. SANT-1 inhibits wild type and oncogenic Smo with equal potency. |
| 别名 | (E)-N-(4-苄基-1-哌嗪基)-1-(3,5-二甲基-1-苯基-1H-吡唑-4-基)甲亚胺;(E)-N-(4-Benzyl-1-piperazinyl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine;(4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine |
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