GF109203X
面议
- 阿拉丁
- 生产商
- 国产
- 上海
- 现货
- 全国
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分子式 C25H24N4O2 分子量412.48 Beilstein号 EC号 MDL号 MFCD00236428 PubChem编号 属性 溶解性 Soluble in DMSO (~1 mg/ml), DMF (10 mg/ml; wa
| 货号 | CAS号 | 操作 |
|---|---|---|
| G129390-1mg | 133052-90-1 | 询底价 |
| G129390-50mg | 133052-90-1 | 询底价 |
| G129390-10mg | 133052-90-1 | 询底价 |
耗材描述
- 分子式 C25H24N4O2
- 分子量412.48
- Beilstein号
- EC号
- MDL号 MFCD00236428
- PubChem编号
属性
| 溶解性 | Soluble in DMSO (~1 mg/ml), DMF (10 mg/ml; warm to 40°C & vortex well), and 1:10 DMSO:PBS (pH 7.2) (~0.1 mg/ml). Insoluble in water. |
| 存贮条件 | 储存温度2-8℃ |
描述
| 应用 | A highly selective inhibitor of all PKC isoforms and slight inhibitor of GSK-3 |
| 产品介绍 | GF109203X是一种有效的PKC抑制剂，抑制PKCα， PKCβI， PKCβII和PKCγ，IC50分别为20 nM， 17 nM， 16nM和20 nM，作用于PKC比作用于EGFR， PDGFR和胰岛素受体选择性高3000倍以上。 |
| 备注 | GF109203X is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor. |
| 生化机理 | Bisindolylmaleimide I (GF 109203X) is a staurosporine inspired molecule, which has been shown to display equally potent inhibition, but with vastly superior selectivity, for all of the known isoforms of PKC (IC50 = 8-20 nM). Inhibition is competitive with respect to ATP, which suggests that Bisindolylmaleimide I occupies the ATP binding domain of the PKC isoforms. Bisindolylmaleimide I (GF 109203X) has been used to selectively probe for PKC-mediated pathways for transduction of hormone, cytokine, and growth factor signals. It inhibits PKC within intact platelets and T cells, Fas-mediated apoptosis, and T cell-mediated autoimmune diseases, as well as GSK-3. |
| 别名 | 3-[1-[3-(二甲氨基)丙基]1H-吲哚-3-基]-4-(吲哚-3-基)1H-吡咯-2,5二酮;;双吲哚马来酰亚胺 I;Bisindolylmaleimide I;3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-Pyrrole-2,5-dione, |
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