SD-208
面议
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分子式 C17H10ClFN6 分子量352.75 MDL号 MFCD11519969 PubChem编号 24899731 属性 沸点 460.41° C at 760 mmHg 熔点 214.79° C 折光率 1.72 溶解性 DMS
| 货号 | CAS号 | 操作 |
|---|---|---|
| S125587-25mg | 627536-09-8 | 询底价 |
| S125587-5mg | 627536-09-8 | 询底价 |
| S125587-100mg | 627536-09-8 | 询底价 |
耗材描述
- 分子式 C17H10ClFN6
- 分子量352.75
- MDL号 MFCD11519969
- PubChem编号 24899731
属性
| 沸点 | 460.41° C at 760 mmHg |
| 熔点 | 214.79° C |
| 折光率 | 1.72 |
| 溶解性 | DMSO >10 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.4900 |
描述
| 应用 | A TGF-β signaling blocker |
| 产品介绍 | SD-208是口服活性的ATP竞争性TGF-βRI抑制剂，IC50为49 nM，比对TGF-βRII和其它激酶的抑制性高100倍和17倍。 |
| 生化机理 | SD-208 is a potent, orally active TGF-βR I kinase inhibitor (TGF-βRI) with IC50 =49 nM based on direct enzymatic assay of TGFRI kinase (ALK5) activity with a specificity of >100-fold against TGFRII and at least 17-fold over members of a panel of related protein kinases including p38a, p38b, p38d, JNK1, EGFR, MAPKAPK2, MKK6, ERK2, PKC, PKA, PKD, CDC2, and CaMKII. SD-208 exhibits anti-inflammatory and antitumor activity. |
| 别名 | SD 208; SD208; SCI 208; 2-(5-氯-2-氟苯基)-N-4-吡啶基-4-蝶啶胺;SD 208; SD208; SCI 208; 2-(5-Chloro-2-fluorophenyl)-N-4-pyridinyl-4-pteridinamine;2-(5-Chloro-2-fluorophenyl)pteridin-4-yl)pyridin-4-yl amine |
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