氯硝柳胺
面议
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分子式 C13H8Cl2N2O4 分子量327.12 Beilstein号 2820605 EC号 200-056-8 MDL号 MFCD00057597 PubChem编号 24278585 属性 熔点 225-230°C 溶解性 Sol
| 货号 | CAS号 | 价格 | 操作 |
|---|---|---|---|
| N130841-50g | 50-65-7 | 面议 | 询底价 |
| N130841-250g | 50-65-7 | 面议 | 询底价 |
| N114456-100mg | 50-65-7 | ￥299.00 | 询底价 |
耗材描述
- 分子式 C13H8Cl2N2O4
- 分子量327.12
- Beilstein号 2820605
- EC号 200-056-8
- MDL号 MFCD00057597
- PubChem编号 24278585
属性
| 熔点 | 225-230°C |
| 溶解性 | Soluble in ethanol (25 mM), DMSO (10 mM), chloroform (very slightly), and methanol: acetone (1: 1) (50 mg/ml). Insoluble in water. |
描述
| 应用 | An inhibitor of the Stat3 signaling pathway and also a FRAP inhibitor. |
| 产品介绍 | Niclosamide is an inhibitor of the Stat3 signaling pathway. Niclosamide inhibits the activation, nuclear translocation and transactivation of Stat3. Niclosamide displays selectivity for Stat3 over Stat1, Stat5, JAK1, JAK2 and Src kinases. Niclosamide inhibits the transcription of Stat3 target genes and induces cell growth inhibition, apoptosis and cell cycle arrest of cancer cells with constitutively active Stat3. Niclosamide is also a FRAP inhibitor via reversible inhibition of mTORC1 signaling and stimulates autophagy in vitro. Niclosamide displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells. |
| 别名 | 2',5-二氯-4'-硝基水杨酸酰替苯胺;4'-硝基-2',5-二氯水杨酰苯胺;百螺杀;见螺杀;血防-67;灭绦录2′,5-Dichloro-4′-nitrosalicylanilide;5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide |
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