耗材描述

• 分子式 C₉H₁₁FN₂O₅
• 分子量246.19
• Beilstein号
• EC号
• MDL号 MFCD00006530
• PubChem编号

属性

熔点	148°C
旋光率	38 ° (C=1, H2O)
敏感性	对热敏感
溶解性	Soluble in water, alcohol, isopropyl alcohol, methanol, aqueous buffers, acetone, dimethyl sulfoxide, and ethanol. Insoluble in ether, benzene and chloroform.
存贮条件	储存温度 2-8℃
密度	1.6400

描述

应用	5-Fluoro-2′-deoxyuridine has been used as a mitotic inhibitor in schwann cell proliferation, glia proliferation and nonneuronal cells in dorsal root ganglion cultures.
产品介绍	5-Fluoro-2′-deoxyuridine, also called floxuridine elicits DNA-directed cytotoxicity in cancer cells. Floxuridine is effective for treating liver cancer and eliminating virulence of Staphylococcus aureus. Dipeptide prodrugs combination of floxuridine with gemcitabine are more cell permeable and display enhanced anti-proliferative activity. Floxuridine is effective on solid tumours and advanced stage cancers.
生化机理	Antineoplastic drug that acts as a potent inhibitor of thymidylate synthetase Resistance to FUdR can develop in cancer cell cultures, among other means, by low-level Mycoplasma infection.
别名	5-氟-2'-脱氧尿苷 ;氟尿苷，氟脲脱氧核苷，氟苷，5-氟-2'-脱氧脲核苷;2′-Deoxy-5-fluorouridine Floxuridine FUDR 1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil

Reaxys-RN	90221
Merck Index	4112
RTECS	YU7525000
UN代码	2811

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