| 应用 |
Minoxidil has been used as test drug:
· in dermal papilla spheroid model, to study the effectof hair regeneration
· administered orally to experimental rats, in theapproach to identify biomarkers of drug induced vascular injury
· administered via oral gavage to nonhuman primate modelin order to study its effect on tilt responses |
| 生化机理 |
Minoxidil is originally used to treat hypertension,which also induces hypertrichosis. It is considered as a potent drug fortreating androgenetic alopecia.
Activates ATP-activated K+ channels;vasodilator; slow or stop hair loss and promote hair regrowth. |
| 别名 |
6-（1-哌啶基）-2,4-嘧啶二胺 3-氧化物, 6-（1-哌啶基）嘧啶-2,4-二胺 3-氧化物；米诺地尔;2,6-二氨基-4-哌啶并嘧啶1-氧化物;;6-(1-Piperidinyl)-2,4-pyrimidinediamine;3-oxide 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide;2,6-Diamino-4-piperidinopyrimidine 1-Oxide |
