犬尿喹啉酸
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分子式 C10H7NO3 分子量189.17 Beilstein号 147451 EC号 207-751-5 MDL号 MFCD00006753 PubChem编号 24277986 属性 熔点 275°C 溶解性 Soluble in w
货号 | CAS号 | 操作 |
---|---|---|
K120012-1g | 492-27-3 | 询底价 |
K120012-250mg | 492-27-3 | 询底价 |
K120012-5g | 492-27-3 | 询底价 |
耗材描述
- 分子式 C10H7NO3
- 分子量189.17
- Beilstein号 147451
- EC号 207-751-5
- MDL号 MFCD00006753
- PubChem编号 24277986
属性
熔点 | 275°C |
溶解性 | Soluble in water (partly), hot alcohol, DMSO (75 mM), 0.1 M NaOH (50 mg/ml), and methanol. |
存贮条件 | 储存温度2-8℃ |
描述
应用 | An antagonist of NMDA and AMPA/kainate receptors |
产品介绍 | Kynurenic acid is a metabolite of tryptophan in mammals via the kynurenine pathway. Studies have observed that Kynurenic acid acts as a ligand to the GPR35 G protein-coupled receptor. The binding of Kynurenic acid to GPR35 has been noted to affect calcium mobilization and inositol phosphatase synthesis and may indicate potential signaling functions by Kynurenic acid via the GPR35 receptor. Additionally reported to be a broad spectrum, excitatory amino acid (EAA) antagonist. Other studies have reported that Kynurenic acid acts as an antagonist to mammalian ionotropic glutamate receptors especially NMDA (N-methyl-D-aspartate receptors).Kynurenic acid is an inhibitor of AChR α7, GluR and GlyR. |
别名 | 4-羟基-2-喹啉甲酸;4-羟基喹啉-2-甲酸;犬尿喹啉酸水合物;4-羟基喹啉-2-羧酸水合物;4-Hydroxyquinaldic Acid; 4-Hydroxyquinoline-2-carboxylic Acid; Kynurenic Acid Hydrate; 4-Hydroxyquinaldic Acid Hydrate; |
标识符号 | GHS07 |
信号词 | Warning |
危害声明 | H315,H319,H335 |
警示性声明 | P261,P305+P351+P338 |
个人防护设备 | dust mask type N95 (US), Eyeshields, Gloves |
WGK德国 | 3 |
风险声明 (欧洲) | R36/37/38 |
安全声明(欧洲) | S26;S36 |
危害码(欧洲) | Xi |
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