Bendamustine HCl
面议
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分子式 C16H21Cl2N3O2·HCl 分子量394.72 Beilstein号 EC号 MDL号 MFCD16879055 PubChem编号 属性 溶解性 Soluble in methanol, DMSO (≥79 mg/ml)
| 货号 | CAS号 | 操作 |
|---|---|---|
| B124707-500mg | 3543-75-7,16506-27-7 | 询底价 |
| B124707-100mg | 3543-75-7,16506-27-7 | 询底价 |
耗材描述
- 分子式 C16H21Cl2N3O2·HCl
- 分子量394.72
- Beilstein号
- EC号
- MDL号 MFCD16879055
- PubChem编号
属性
| 溶解性 | Soluble in methanol, DMSO (≥79 mg/ml) at 25° C, water (≥15 mg/ml) at 25° C, and ethanol (≥17 mg/ml) at 25° C. |
| 存贮条件 | 储存温度：室温 |
描述
| 应用 | A nitrogen mustard purine analog alkylator |
| 产品介绍 | Bendamustine HCL是一种DNA损伤剂，无细胞试验中IC50为50 μM。 |
| 生化机理 | Bendamustine Hydrochloride is a small molecule bifunctional DNA alkylating agent, combining a nitrogen mustard functionality with a purine-analog structure. The dense DNA-damaging functionality of Bendamustine differentiates it from other compounds used as antiproliferative agents, and these functionalities are thought to promote cell death through a variety of different pathways including apoptosis and mitotic catastrophe. Accordingly it has been indicated for use in treating proliferations and malignancies refractory to the effects of other DNA alkylators. Efficacy against chronic lymphocytic leukemia is particularly indicated with Bendamustine, presenting a potential intervention upon this notoriously variable and ubiquitous type of malignancy. |
| 别名 | 盐酸苯达莫司汀水合物;5-[二(2-氯乙基)氨基]-1-甲基苯并咪唑-2-丁酸盐酸盐 水合物;Bendamustine hydrochloride;5-[Bis(2-chloroethyl)-amino]-1-methyl-1H-benzimidazole-2-butanoic Acid Hydrochloride;Ribomustin HCl; Treanda HCl; SDX-105 HCl; 1H-Benzimidazole-2-butanoic acid; 5-[bis(2-chloroethyl)amino]-1-methyl monohydrochloride |
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