Wortmannin
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分子式 C23H24O8 分子量428.43 Beilstein号 67676 MDL号 MFCD00133927 PubChem编号 24278777 属性 敏感性 对热、湿度和光线敏感 溶解性 Soluble in DMSO (50 m
| 货号 | CAS号 | 操作 |
|---|---|---|
| W100984-5mg | 19545-26-7 | 询底价 |
| W100984-10mg | 19545-26-7 | 询底价 |
| W100984-25mg | 19545-26-7 | 询底价 |
耗材描述
- 分子式 C23H24O8
- 分子量428.43
- Beilstein号 67676
- MDL号 MFCD00133927
- PubChem编号 24278777
属性
| 敏感性 | 对热、湿度和光线敏感 |
| 溶解性 | Soluble in DMSO (50 mg/ml), ethanol (25 mg/ml), methanol, 1:8 DMSO:PBS(pH 7.2) (~0.1 mg/ml), and DMF (~14 mg/ml). |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.3900 |
描述
| 应用 | A fungal metabolite which inhibits Pl3-kinase |
| 产品介绍 | Wortmannin是一种PI3K抑制剂，IC50为3 nM，抑制自噬体的形成，也有效抑制DNA-PK/ATM，IC50分别为16 nM和150 nM。 |
| 生化机理 | Wortmannin, a fungal metabolite, is a potent and selective inhibitor of PI 3-kinase. Wortmannin inhibits repair of DNA double-strand breaks in irradiated normal human cells. Wortmannin displays a similar potency in vitro for the class I, II, and III PI 3-kinase members, although it can also inhibit other PI 3-kinase-related enzymes such as FRAP (mTOR), DNA-PKCS, some phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK) at high concentrations. Wortmannin has also been reported to inhibit members of the polo-like kinase family with IC50 in the same range as for PI 3-kinase. The half-life of Wortmannin in tissue culture is about 10 minutes due to the presence of the highly reactive C20 carbon that is also responsible for its ability to covalently inactivate PI 3-kinase. Wortmannin is an inhibitor of Fnk and Plk |
| 别名 | KY 12420;抗生素SL-2052;KY 12420;Antibiotic SL-2052 |
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