衣霉素
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分子式 C38H62N4O16 (Tun B) 分子量840 Beilstein号 6888090 EC号 MFCD00065709 MDL号 MFCD00065709 PubChem编号 24900473 属性 溶解性 Soluble i
| 货号 | CAS号 | 操作 |
|---|---|---|
| T101151-10mg | 11089-65-9 | 询底价 |
| T101151-1mg | 11089-65-9 | 询底价 |
| T101151-50mg | 11089-65-9 | 询底价 |
| T101151-5mg | 11089-65-9 | 询底价 |
耗材描述
- 分子式 C38H62N4O16 (Tun B)
- 分子量840
- Beilstein号 6888090
- EC号 MFCD00065709
- MDL号 MFCD00065709
- PubChem编号 24900473
属性
| 溶解性 | Soluble in water (partly miscible), alkaline water, pyridine, hot methanol, DMSO (>10 mg/ml), ethanol (5 mg/ml, warm), butanol (slightly), and DMF. Insoluble in acetone, ethyl acetate, chloroform, benzene, and acidic water. |
| 存贮条件 | 储存温度2-8℃ |
| 密度 | 1.5700 |
描述
| 应用 | A competitive cell cycle inhibitor |
| 产品介绍 | Tunicamycin is a mixture of Tunicamycins A, B, C and D which has been widely used in the study of glycoprotein synthesis in various biological systems. Tunicamycin inhibits GNPTAB (GlcNAc phosphotransferase, GPT) and inhibts the formation of N-glycosidic linkages in glycoprotein synthesis. Tunicamycin has also been reported to have a dose-dependent inhibition of DNA synthesis, to inhibit protein glycosylation, to suppress the S-phase of the cell cycle, and to arrest the cell cycle in late G1. As a member of a family of antibiotics produced by Streptomyces lysosuperficus, this compound is noted to be active in vitro against gram-positive bacteria, fungi, yeasts and viruses. During protein glycosylation, tunicamycin is noted to be an inhibitor of the transfer of saccharide moieties to dolichol during dolichol-linked glycoprotein synthesis. Dose-dependent inhibition of DNA synthesis may be related to the alteration of glycoproteins, which thereby affects the transport of thymidine into cells. Additionally, tunicamycin has been reported to prevent cell cycle progression in primary cultures of rat glial cells, as well as inhibit lipid-mediated protein glycosylation in chick or mouse fibroblasts in a dose-dependent manner. |
| 生化机理 | Antibacterial and antifungal. Blocks the formation of protein N-glycosidic linkages by inhibiting the transfer of N-acetylglucosamine 1-phosphate to dolichol monophosphate. Inhibits bacterial and eukaryote N-acetylglucosamine transferases and prevents formation of N-acetylglucosamine lipid intermediates. |
| 别名 | ; |
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