耗材描述

• 分子式 C₁₈H₁₆O₈
• 分子量360.31
• Beilstein号 2227587
• MDL号 MFCD00017740
• PubChem编号 24878185

属性

熔点	171-175°C
敏感性	对空气敏感
溶解性	Soluble in water (100 mM), ethanol (~25 mg/ml), DMSO (~25 mg/ml), DMF (~25 mg/ml), and PBS (pH 7.2) (~15 mg/ml).
存贮条件	充氩保存

描述

应用	An activator of GPR35.
生化机理	Rosmarinic Acid is a phenylpropanoid isolated from Labiatae herbs. The compound exhibits antiinflammatory activity and inhibits the proliferation of murine mesangial cells. Rosmarinic Acid has been shown to dose dependently inhibit migration, adhesion, and invasion of Ls174-T human colon carcinoma cells. Rosmarinic Acid has been documented to increase the melanin content in B16 melanoma cells through activation of protein kinase A. In the same study rosmarinic acid induced the phosphorylation of CRE-binding protein (CREB) and activated cAMP response element (CRE). In the classical complement pathway Rosmarinic Acid inhibited C3-convertase. It also has shown to be an activator of GPR35.
别名	(R)-O-(3,4-二羟基肉桂酰)-3-(3,4-二羟苯基)乳酸;3,4-二羟基肉桂酸;(R)-1-羧基-2-(3,4-二羟苯)乙酯(R)-O-(3,4-Dihydroxycinnamoyl)-3-(3,4- dihydroxyphenyl)lactic acid;3,4-Dihydroxycinnamic acid (R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethyl ester

个人防护设备	Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
WGK德国	3

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