I127127-25mgIOX2
面议
- 阿拉丁
- 生产商
- I127127-25mg
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C19H16N2O5
- 分子量352.34
属性
溶解性 | DMSO 100 mg/ml |
存贮条件 | 储存温度2-8℃ |
描述
产品介绍 | IOX2是低氧诱导因子(HIF)脯氨酰羟化酶(PHD)抑制剂,在细胞中对PHD2/ELGN-1的IC50为21 nM,对FIH无活性。 |
备注 | IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH. |
生化机理 | IOX2 is selective and potent inhibitor of prolyl hydroxylases (PHD). Stabilization of HIF-1R through inhibition of PHD has been examined as a potential treatment for ischemic diseases including anemia, myocardial infarction, and stroke. IOX2 is a selective inhibitor of the hypoxia inducible factor (HIF) prolyl-hydroxylases (PHD) that exhibits up-regulation of HIF1a in zebrafish. |
别名 | IOX 2;IOX-2;JICL38;N-((4-羟基-2-氧代-1-(苯基甲基)-1,2-二氢-3-喹啉基)羰基)甘氨酸;;IOX 2;IOX-2;JICL38; N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]-glycine; N-[[4-Hydroxy-2-oxo-1-(phenylmethyl)-1,2-dihydro-3-quinolinyl]carbonyl]glycine |
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