N129966-25mgNSC 319726
面议
- 阿拉丁
- 生产商
- N129966-25mg
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C11H14N4S
- 分子量234.32
属性
溶解性 |
|
存贮条件 | 储存温度-20°C |
描述
产品介绍 | NSC319726是突变型p53R175再活化剂,能抑制表达p53R175的成纤维细胞增殖,IC50值为8nM,对野生型p53细胞无抑制作用。 |
生化机理 | NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells, shows 10- to 100-fold selectivity over the other hotspot p53 mutants. NSC319276 induces p53(R175)-mutant-dependent apoptosis. NSC319726 treatment induces a WT-like conformational change in the p53(R175) mutant protein that restores sequence-specific p53 transcription. The activity of NSC319726 depends on the zinc ion chelating properties of the compound as well as redox changes. |
别名 | NSC-319726;1-吖丁啶硫代羧酸[1-(2-吡啶基)亚乙基]酰肼;NSC-319726;1-Azetidinecarbothioic acid [1-(2-pyridinyl)ethylidene]hydrazide;[1-(2-Pyridinyl)ethylidene]hydrazide 1-Azetidinecarbothioic Acid |
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