A125698-50mgABT-751 (E7010)
面议
- 阿拉丁
- 生产商
- A125698-50mg
- 现货
- 全国
规格 |
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耗材描述
属性
溶解性 | DMSO ≥73mg/mL Water <1.2mg/mL Ethanol ≥13mg/mL |
存贮条件 | 储存温度2-8℃ |
描述
应用 | An inhibitor of microtubule polymerization |
产品介绍 | ABT-751(E 7010)是新型的生物相容性的微管蛋白结合剂和抗有丝分裂磺胺类化合物,对神经母细胞瘤细胞株和非神经母细胞瘤细胞株的IC50分别为1.5 和 3.4 |
备注 | ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2. |
生化机理 | ABT-751(E 7010) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively |
别名 | ABT751; ABT 751; E7010; E-7010; E 7010; N-(2-((4-羟基苯基)氨基)-3-吡啶基)-4-甲氧基苯磺酰胺;N-(2-(4-hydroxyphenylamino)pyridin-3-yl)-4-methoxybenzenesulfonamide;ABT751; ABT 751; E7010; E-7010; E 7010; |
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