M129586-200mgMontelukast sodium hydrate
面议
- 阿拉丁
- 生产商
- M129586-200mg
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C35H35ClNO3S·Na · xH2O
- 分子量608.17 (anhydrous basis)
- Beilstein号
- EC号
- MDL号 MFCD00931431
- PubChem编号
属性
旋光率 | +95.0 to +105.0 deg(C=1、MeOH) |
敏感性 | 对湿度敏感;对空气敏感;对光线敏感 |
溶解性 |
|
存贮条件 | 储存温度2-8℃ |
描述
应用 | Montelukast sodium hydrate is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. It is a subtype specific CysLT1 receptor antagonist. |
备注 | Montelukast selectively antagonizes leukotriene D 4 (LTD4) by binding to it so that block the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1. |
生化机理 |
Montelukast Sodium(Singulair) is a potent, selective, anti-inflammatory CysLT1 receptor antagonist (IC50 < 5nM) with no appreciable affect on the CysLT2 receptor. In rat colitis Montelukast Sodium (Singulair) has demonstrated the ability to increase PGE2 production and lower COX-2 expression. Inhibition is competitive with respect to leukotrienes - particularly LTD4, a biologically active mediator that plays an important role in the control of several biochemical pathways involving pulmonary and immune system function. |
别名 | 孟鲁司特钠 水合物;1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid sodium salt hydrate |
Reaxys-RN | 7617467 |
RTECS | GZ0698000 |
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