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血管生成
FG-4592
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| F126178-250mg | 808118-40-3 | 询价 |
| F126178-50mg | 808118-40-3 | 询价 |
| F126178-10mg | 808118-40-3 | 询价 |
产品介绍
属性
| 溶解性 | DMSO >70 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度2-8°C |
描述
| 产品介绍 | FG-4592是一种HIF α脯氨酰羟化酶抑制剂，并能稳定HIF-2，同时诱导EPO产生。 |
| 备注 | FG-4592 is an HIF αprolyl hydroxylase inhibitor, stabilizes HIF-2 and induces EPO production. Phase 2/3. |
| 生化机理 |
FG-4592 is an inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase currently in clinical development for the treatment of anemia. FG-4592 stabilizes the activities of HIF, a cytosolic transcription factor, leading to activation of the genes associated with erythropoiesis, including erythropoietin and enzymes involved in iron metabolism. A phase II clinical trial of FG-4592 has been competed in the treatment of chronic kidney disease. |
| 别名 | N-[(4-羟基-1-甲基-7-苯氧基-3-异喹啉基)羰基]甘氨酸;FG4592;FG 4592;N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine;[[(4-Hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)carbonyl]amino]acetic acid |
FG-4592信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于FG-4592报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途