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PHA-793887

品牌 厂商性质 产地 货期
阿拉丁 生产商 上海 现货

询底价
产品参数
货号 CAS号 操作
P127795-10mg 718630-59-2 询底价
P127795-50mg 718630-59-2 询底价
P127795-5mg 718630-59-2 询底价
产品介绍

  • 分子式 C19H31N5O2
  • 分子量361.48
  • Beilstein号
  • EC号
  • MDL号
  • PubChem编号

属性

溶解性 DMSO ≥70mg/mL Water <1.2mg/mL Ethanol ≥70mg/mL
存贮条件 储存温度-20°C

描述

应用 a novel pan-Cdk inhibitor inactive against 34 other kinases.
产品介绍 PHA-793887是一种新型有效的CDK2,CDK5和CDK7抑制剂,IC50分别为8 nM, 5 nM 和10 nM,作用于CDK2, 5,和7比作用于CDK1, 4,和9选择性高6倍以上。
备注 PHA-793887 is a novel and potent inhibitor of CDK2, CDK5 and CDK7 with IC50 of 8 nM, 5 nM and 10 nM. It is greater than 6-fold more selective for CDK2, 5, and 7 than CDK1, 4, and 9. Phase 1.
生化机理 PHA-793887 is a novel pan-Cdk inhibitor, including Cdk1, Cdk2, Cdk4, Cdk5, Cdk7, and Cdk9 with IC50’s in the 5 to 140 nM range. PHA-793887 is inactive against 34 other kinases representative of all kinase families, in particular c-abl, c-kit, lck, and TRKA with IC50>10 mM. PHA-793887 shows anti-proliferative activity against several solid tumor cell lines, with IC50<1 mM; in these cells, it is able to inhibit Rb phosphorylation and expression of S-phase cyclins, such as cyclin A.
别名 PHA 793887;PHA793887; 3-甲基-N-[1,4,5,6-四氢-6,6-二甲基-5-[(1-甲基-4-哌啶基)甲酰基]吡咯并[3,4-c]吡唑-3-基]丁酰胺;PHA 793887;PHA793887;3-Methyl-N-[1,4,5,6-tetrahydro-6,6-dimethyl-5-[(1-methyl-4-piperidinyl)carbonyl]pyrrolo[3,4-c]pyrazol-3-yl]butanamide

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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途