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干细胞/祖细胞
IWP-2
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| I126927-10mg | 686770-61-6 | 询价 |
| I126927-50mg | 686770-61-6 | 询价 |
产品介绍
- 分子式 C22H18N4O2S3
- 分子量466.6
- MDL号 MFCD04457599
属性
| 沸点 | 723.12° C |
| 熔点 | 316.82° C |
| 溶解性 |
|
| 存贮条件 | 储存温度2-8℃ |
描述
| 应用 | An inhibitor of Wnt production |
| 产品介绍 | IWP-2 是Porcn功能钝化剂，IC50为27 nM，是Wnt生成抑制剂。 |
| 生化机理 | IWP-2 is an inactivator of Porcn function; inhibitor of Wnt production. Wnt/b-catenin (‘canonical’) pathway maintains transcriptional programs that enable stem cells to remain multipotent. Hyperactivation of the Wnt/b-catenin pathway leads to disease stage. IWP-2 inhibits Wnt production. It appears that IWP inactivates Porcn function either by directly inhibiting the Porcn active site or by modulating the function of a Porcn regulator. Porcn is a member of the membrane-bound O-acyltransferase (MBOAT) family, which adds a palmitoyl group to Wnt proteins that is essential to their signaling ability and is required for Wnt secretion. IWP-2 is useful in both regenerative medicine and anticancer efforts. |
| 别名 | IWP 2; N-(6-甲基-2-苯并噻唑基)-2-((3,4,6,7-四氢-4-氧代-3-苯基噻吩并(3,2d)嘧啶-2-基)硫基)乙酰胺;;IWP 2; N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide |
IWP-2信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于IWP-2报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途