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干细胞/祖细胞

Cyclopamine

品牌 厂商性质 产地 货期
阿拉丁 生产商 上海 现货

询价
产品参数
货号 CAS号 操作
C125994-10mg 4449-51-8 询价
C125994-50mg 4449-51-8 询价
C125994-5mg 4449-51-8 询价
产品介绍

  • 分子式 C27H41NO2
  • 分子量411.62

属性

溶解性 Soluble in ethanol (5 mg/ml warm), DMSO (4 mg/ml), DMF (10 mg/ml), methylene chloride, chloroform, methanol (7 mg/ml), and benzene
存贮条件 储存温度2-8℃

描述

应用 A hedgehog [Hh] signaling pathway and Smo inhibitor.
产品介绍 Cyclopamine是一种特异性的Hedgehog (Hh)信号通路拮抗剂,作用于Smoothened (Smo),IC50为46 nM。
备注 Cyclopamine is a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM.
生化机理 Cyclopamine is a teratogenic Smo inhibitor famous for inducing cyclopia in developing mammalian fetuses. Cyclopia arises from improper differentiation in the fetus, a process heavily regulated by the Hedgehog (Hh) signaling pathway. The proteins Smo and patched mediate cellular response to the Hedgehog protein signal, and aberrant behavior of these proteins can lead to oncogenic states. While cyclopia and fetal failure are the notorious effects of cyclopamine on development, the compound has also been used to suppress and reverse the effects of oncogenic mutations in Smo and patched.
别名 环巴胺; 去氧芥芬胺;11-Deoxojervine; (3b,23b)-17,23-Epoxy-11-deoxoveratraman-3-ol

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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途