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点击这里给上海阿拉丁生化科技股份有限公司

干细胞/祖细胞

PF-5274857

PF-5274857
品牌 厂商性质 产地类别 产地
阿拉丁 生产商 国产 上海

询价
产品参数
货号 CAS号 操作
P126554-10mg 1373615-35-0 询价
P126554-1mg 1373615-35-0 询价
P126554-50mg 1373615-35-0 询价
P126554-5mg 1373615-35-0 询价
产品介绍

  • 分子式 C20H25ClN4O3S
  • 分子量436.96

属性

溶解性
  • DMSO 93 mg/mL
  • Water 93 mg/mL
  • Ethanol <1 mg/mL
  • 存贮条件 储存温度-20°C

    描述

    备注 PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier.
    生化机理

    PF-5274857 is a novel Smo antagonist that specifically binds to Smo with a K(i) of 4.6 ± 1.1 nmol/L and completely blocks the transcriptional activity of the downstream gene Gli1 with an IC(50) of 2.7 ± 1.4 nmol/L in cells. This Smo antagonist PF-5274857 showed robust antitumor activity in a mouse model of medulloblastoma with an in vivo IC(50) of 8.9 ± 2.6 nmol/L. PF-5274857 was orally available and metabolically stable in vivo. PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor types including brain tumors and brain metastasis driven by an activated Hedgehog (Hh) signaling pathway.

    别名 1-(4-(5-chloro-4-(3,5-dimethylpyridin-2-yl)pyridin-2-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one;1-(4-(5-chloro-4-(3,5-dimethylpyridin-2-yl)pyridin-2-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one

    PF-5274857信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于PF-5274857报价、型号、参数等信息,欢迎来电或留言咨询。

    注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途