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干细胞/祖细胞
Purmorphamine
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
货号 | CAS号 | 操作 |
---|---|---|
P126030-100mg | 483367-10-8 | 询价 |
P126030-10mg | 483367-10-8 | 询价 |
P126030-25mg | 483367-10-8 | 询价 |
P126030-5mg | 483367-10-8 | 询价 |
产品介绍
属性
溶解性 | Soluble in DMSO (10 mM), DMF (~20 mg/ml), DMF:PBS(pH 7.2) (1:1) (~0.25 mg/ml), and chloroform. |
存贮条件 | 储存温度-20°C |
描述
应用 | An activator of the hedgehog (Hh) signaling pathway. |
产品介绍 | Purmorphamine与Smo拮抗剂竞争性结合到Smoothened,并激活Smoothened,IC50约为1.5 μM,也诱导成骨细胞分化,EC50为1μM。 |
备注 | Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM and also is an inducer of osteoblast differentiation with EC50 of 1 μM. |
生化机理 | Purmorphamine, a purine derivative, has been shown to activate the Hedgehog (Hh) signaling pathway which is important for regulating embryonic patterning, stem cell renewal, and tissue regeneration. Additionally, this compound has been noted to display osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. Similar studies have reported purmorphamine to enhance events related to osteoblast differentiation. Purmorphamine is an activator of Smo. |
别名 | 9-环己基-N-[4-(4-吗啉基)苯基]-2-(1-萘氧基)-9H-嘌呤-6-胺;2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine; 9-cyclohexyl-N-[4-(morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine |
Purmorphamine信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于Purmorphamine报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途