400-6699-1171000

分析测试百科网 认证会员,请放心拨打!

首页> 产品展示> Purmorphamine

诚信认证:

工商注册信息已核实!

产品分类
微信二维码
QQ号咨询

点击这里给上海阿拉丁生化科技股份有限公司

干细胞/祖细胞

Purmorphamine

品牌 厂商性质 产地 货期
阿拉丁 生产商 上海 现货

询价
产品参数
货号 CAS号 操作
P126030-100mg 483367-10-8 询价
P126030-10mg 483367-10-8 询价
P126030-25mg 483367-10-8 询价
P126030-5mg 483367-10-8 询价
产品介绍

  • 分子式 C31H32N6O2
  • 分子量520.62
  • Beilstein号
  • EC号
  • MDL号
  • PubChem编号

属性

溶解性 Soluble in DMSO (10 mM), DMF (~20 mg/ml), DMF:PBS(pH 7.2) (1:1) (~0.25 mg/ml), and chloroform.
存贮条件 储存温度-20°C

描述

应用 An activator of the hedgehog (Hh) signaling pathway.
产品介绍 Purmorphamine与Smo拮抗剂竞争性结合到Smoothened,并激活Smoothened,IC50约为1.5 μM,也诱导成骨细胞分化,EC50为1μM。
备注 Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM and also is an inducer of osteoblast differentiation with EC50 of 1 μM.
生化机理 Purmorphamine, a purine derivative, has been shown to activate the Hedgehog (Hh) signaling pathway which is important for regulating embryonic patterning, stem cell renewal, and tissue regeneration. Additionally, this compound has been noted to display osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. Similar studies have reported purmorphamine to enhance events related to osteoblast differentiation. Purmorphamine is an activator of Smo.
别名 9-环己基-N-[4-(4-吗啉基)苯基]-2-(1-萘氧基)-9H-嘌呤-6-胺;2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine; 9-cyclohexyl-N-[4-(morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine

Purmorphamine信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于Purmorphamine报价、型号、参数等信息,欢迎来电或留言咨询。

注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途