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聚合试剂
N,N,N',N'-四(2-吡啶甲基)乙二胺
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| N159625-1G | 16858-02-9 | 询价 |
| N159625-250mg | 16858-02-9 | 询价 |
| N159625-5G | 16858-02-9 | 询价 |
产品介绍
- 分子式 C26H28N6
- 分子量424.55
- Beilstein号
- EC号
- MDL号 MFCD00036918
- PubChem编号
属性
描述
| 应用 |
N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine has been used: · in the treatment of human embryonic kidney (HEK293T) cells for assessing its effect on the Jembrana disease virus (JDV) viral infectivity factor (Vif) functionality · in P19 embryonic carcinoma cells for chelation of zinc ions released during apoptosis · to evaluate its effect on lentiviral Vpx infection on human monocytic THP-1 cells |
| 生化机理 | N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) elicits pro-apoptotic effect in human acute promyelocytic NB4 cells by inhibiting nitric oxide signalling and Zn2+ signaling.[1] In microglia pretreated with zinc, TPEN inhibits the interleukin 6 secretion and nitric oxide synthase (iNOS) mRNA expression.[2] It induces damage on DNA structure by activating ATM (ataxia telangiectasia mutated) and ATR (ATM-Rad3-related) signaling in human colon cancer cells. TPEN是一种可透过膜的锌螯合剂；可降低细胞内锌水平并诱导细胞凋亡（即细胞收缩和凋亡小体的形成、DNA片段化和形成典型的DNA梯状带）。 |
| 别名 | ;TPEN;TPEDA |
N,N,N',N'-四(2-吡啶甲基)乙二胺信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于N,N,N',N'-四(2-吡啶甲基)乙二胺报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途