替普瑞酮与其异构体在ChromCore C30色谱柱上的分离

Column: ChromCore C30, 5 μm
Dimension: 4.6×250 mm
Mobile Phase: A) 水
B) 乙腈
Gradient: t (min) %A %B
0 40 60
20 40 60
170 25 75
180 10 90
190 10 90
Flow Rate: 1.0 mL/min
Temperature: 20 °C
Injection: 5 μL
Detection: UV 205 nm
Peaks: 1~4. Teprenone Isomer (替普瑞酮杂质)
5~6. Teprenone (替普瑞酮及其异构体)